Advances in Animal and Veterinary Sciences

Research Article
Adv. Anim. Vet. Sci. 4(12): 648-654
Http://dx.doi.org/10.14737/journal.aavs/2016/4.12.648.654
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Sarvesha Krishnappa, Mayasandra Lakshmikanth Satyanarayana, Suguna Rao, Sreenivasa Yathiraj, Narayana Bhat Shridhar, Shivalingappa Yamanappa Mukartal, Saurabh Gupta, Shoorvir Singh, Kuldeep Dhama, Anuradha Menon Elattuvalappil 

Department of Pathology, Veterinary College, Hebbal, KVAFSU, Bengaluru- 560 024; 2Veterinary College, Hebbal, KVAFSU, Bengaluru 560 024; 3Department of Pharmacology and Toxicology; 4Department of Veterinary Microbiology, Veterinary College, Hebbal, KVAFSU, Bengaluru-560 024; 5Division of Animal Health, Central Institute for Research on Goats (CIRG), Makhdoom, PO-Farah, Mathura-281122, Uttar Pradesh, India; 6Division of Pathology, Indian Veterinary Research Institute (IVRI), Bareilly, Uttar Pradesh; 7ICAR NAE Project, Veterinary College, Bengaluru, India.
 
Abstract | The aim of the study was to evaluate the hepatoprotective effect of AGE in AFB1 induced liver damage in Wistar albino rats. Liver damage was induced by inoculating AFB1 (4 mg/kg BW) on day 12 of the experiment. AGE was used (200 mg/kg BW) orally, for a period of 28 days against AFB1 induced liver injury. Histopathologically there was periportal and centrilobular necrosis of hepatocytes and bile duct hyperplasia in AFB1 treated rats, however, when AGE was given along with AFB1 the hepatic parenchyma was apparently normal indicating the beneficial effect of AGE in protecting liver against AFB1 induced injury.

Keywords | Aged garlic extract (AGE), Aflatoxin B1 (AFB1), Bile duct hyperplasia, Histhopathology, Aspergillus